Biochemical and cellular mechanism of protein kinase CK2 inhibition by deceptive curcumin
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چکیده
منابع مشابه
Structural bases of protein kinase CK2 inhibition
CK2, one of the first protein kinase ever discovered, is an eukaryotic acidophilic Ser/Thr protein kinase. CK2 is considered a quite anomalous protein kinase for the following peculiar properties: i) it is highly pleiotropic, ii) it can use both ATP and GTP as co-substrate, iii) the target ser-ine or threonine must be surrounded by acidic residues (with the minimal consensus sequence Ser/Thr-X-...
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Glomerulonephritis (GN) is a progressive inflammation that may be caused by a variety of underlying disorders. It is the primary cause of chronic renal failure and end-stage renal disease, which require dialysis and transplantation worldwide. Immunosuppressive therapy has been used to treat GN clinically, but this treatment has had insufficient therapeutic effects. Here, we show that protein ki...
متن کاملProtein Kinase CK2: Intricate Relationships within Regulatory Cellular Networks
Protein kinase CK2 is a small family of protein kinases that has been implicated in an expanding array of biological processes. While it is widely accepted that CK2 is a regulatory participant in a multitude of fundamental cellular processes, CK2 is often considered to be a constitutively active enzyme which raises questions about how it can be a regulatory participant in intricately controlled...
متن کاملProtein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism
Neointimal hyperplasia is a product of VSMC replication and consequent accumulation within the blood vessel wall. In this study, we determined whether inhibition of protein kinase CK2 and the resultant stabilisation of proline-rich homeodomain (PRH) could suppress VSMC proliferation. Both silencing and pharmacological inhibition of CK2 with K66 antagonised replication of isolated VSMCs. SiRNA-i...
متن کاملProtein kinase CK2.
Protein kinase CK2 is a ubiquitous protein kinase responsible for the phosphorylation of Ser and Thr residues specified by acidic side chains in many proteins, including several key enzymes, growth factor receptors, transcription factors and cytoskeletal proteins. The holoenzyme is composed of two catalytic and two regulatory subunits, the latter having antagonistic roles. CK2 is constitutively...
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ژورنال
عنوان ژورنال: The FEBS Journal
سال: 2019
ISSN: 1742-464X,1742-4658
DOI: 10.1111/febs.15111